EEG biomarkers differentiate Lewy Body Dementia from Alzheimer’s disease
Poster presentation at Alzheimer's Association International Conference (AAIC 2021). Resting state electroencephalography (rsEEG) is a neurophysiologic Alzheimer disease (AD) and alpha-synucleinopathy (dementia with Lewy body (DLB) and Parkinson disease (PDD)) biomarker. Background slowing (increased low frequency power, dominant rhythm (DR) slowing) is frequent in AD and DLB, more so in DLB. We sought to identify distinguishing rsEEG signatures between DLB and AD.
Conclusions: DLB and AD had both common and distinct rsEEG signatures. Both had DR slowing and background slowing that was more severe in DLB than AD. Distinctive DLB findings included reduced posterior DR spatial dominance and decreased delta coherence. Conversely, distinct AD features were increased delta coherence, decreased alpha power, and decreased DR frequency prominence. Finally, the DLB and PDD groups had a similar magnitude of DR slowing, consistent with posteriorly dominant functional impairment in synucleinopathy reflected by corresponding regional rsEEG slowing, although future longitudinal prospective sequential rsEEG analyses are necessary to confirm these findings.